KAAD-Cyclopamine(Synonyms: Cyclopamine-KAAD)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KAAD-Cyclopamine (Synonyms: Cyclopamine-KAAD)

KAAD-Cyclopamine 是 hedgehog 信号通路的抑制剂，是 smoothened 的拮抗剂。

KAAD-Cyclopamine(Synonyms: Cyclopamine-KAAD)

KAAD-Cyclopamine Chemical Structure

CAS No. : 306387-90-6

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生物活性

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

体外研究
(In Vitro)

KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

697.99

Formula

C44H63N3O4
CAS 号

306387-90-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30.

    [2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.

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