C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

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C12-Ceramide (Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺，由 C12 鞘磷脂水解形成。C12-Ceramide 可以增强 MDA-MB-231 细胞中 Doxorubicin 的毒性。C12-Ceramide 还可用于诊断 A 型和 B 型尼曼匹克症。

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide Chemical Structure

CAS No. : 74713-60-3

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生物活性

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

体外研究
(In Vitro)

C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

481.79

Formula

C30H59NO3
CAS 号

74713-60-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

    [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

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