C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

C12-Ceramide (Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺，由 C12 鞘磷脂水解形成。C12-Ceramide 可以增强 MDA-MB-231 细胞中 Doxorubicin 的毒性。C12-Ceramide 还可用于诊断 A 型和 B 型尼曼匹克症。

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide Chemical Structure

CAS No. : 74713-60-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

体外研究
(In Vitro)

C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

481.79

Formula

C30H59NO3
CAS 号

74713-60-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

    [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务