Norathyriol(Synonyms: Mangiferitin)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Norathyriol (Synonyms: Mangiferitin)

Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )，IC50 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ，IC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

Norathyriol(Synonyms: Mangiferitin)

Norathyriol Chemical Structure

CAS No. : 3542-72-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

IC50 & Target[2]

PPARα

92.8 μM (IC50)

PPARβ

102.4 μM (IC50)

PPARγ

153.5 μM (IC50)

体外研究
(In Vitro)

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse skin epidermal JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 24 or 72 hours
Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis[3]

Cell Line: JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 2 hours
Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

体内研究
(In Vivo)

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Kunming mice weighing 18-22 g[4]
Dosage: 0.92, 1.85 and 3.7 mg/kg
Administration: Administered intragastrically; twice daily for five times
Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

分子量

260.20

Formula

C13H8O6
CAS 号

3542-72-1
中文名称

芒果苷元
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015.

    [2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42.

    [3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70.

    [4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务