Norathyriol(Synonyms: Mangiferitin)

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Norathyriol (Synonyms: Mangiferitin)

Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )，IC50 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ，IC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

Norathyriol(Synonyms: Mangiferitin)

Norathyriol Chemical Structure

CAS No. : 3542-72-1

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生物活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

IC50 & Target[2]

PPARα

92.8 μM (IC50)

PPARβ

102.4 μM (IC50)

PPARγ

153.5 μM (IC50)

体外研究
(In Vitro)

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse skin epidermal JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 24 or 72 hours
Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis[3]

Cell Line: JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 2 hours
Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

体内研究
(In Vivo)

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Kunming mice weighing 18-22 g[4]
Dosage: 0.92, 1.85 and 3.7 mg/kg
Administration: Administered intragastrically; twice daily for five times
Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

分子量

260.20

Formula

C13H8O6
CAS 号

3542-72-1
中文名称

芒果苷元
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015.

    [2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42.

    [3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70.

    [4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

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