Thalidomide-5-methyl

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Thalidomide-5-methyl 

Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体，用于CRBN 蛋白招募。

Thalidomide-5-methyl

Thalidomide-5-methyl Chemical Structure

CAS No. : 40313-92-6

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生物活性

Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

272.26

Formula

C14H12N2O4
CAS 号

40313-92-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.

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