BRD-8899

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

BRD-8899 

BRD-8899是STK33 的抑制剂,其 IC50 值为 11 nM。

BRD-8899

BRD-8899 Chemical Structure

CAS No. : 1404437-50-8

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生物活性

BRD-8899 is a STK33 inhibitor, with an IC50 of 11 nM[1].

IC50 & Target

IC50: 11 nM (STK33)[1].

体外研究
(In Vitro)

BRD8899 (1, 10, 20 μM, 24 h) results in decreased phosphorylation of the MST4 substrate ezrin in NOMO-1 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NOMO-1 cells.
Concentration: 1, 10, 20 μM.
Incubation Time: 24 h.
Result: Decreased p-Ezrin levels.

分子量

362.45

Formula

C17H22N4O3S

CAS 号

1404437-50-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tuoping Luo, et al. STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5.

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