Pomalidomide-5-OH(Synonyms: 5-Hydroxy pomalidomide; CC-17368)

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Pomalidomide-5-OH (Synonyms: 5-Hydroxy pomalidomide; CC-17368)

Pomalidomide-5-OH (5-hydroxy pomalidomide) 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Pomalidomide-5-OH 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Pomalidomide-5-OH(Synonyms: 5-Hydroxy pomalidomide; CC-17368)

Pomalidomide-5-OH Chemical Structure

CAS No. : 1547162-41-3

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生物活性

Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

289.24

Formula

C13H11N3O5
CAS 号

1547162-41-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501.

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