CC-17369(Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16)

发表于由

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CC-17369 (Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16)

CC-17369 (7-Hydroxy pomalidomide) 是 Pomalidomide 的代谢物。CC-17369 基于泊马利度胺的cereblon (CRBN) 配体。CC-17369 可通过连接物连接到蛋白质配体合成 PROTAC。

CC-17369(Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16)

CC-17369 Chemical Structure

CAS No. : 1547162-46-8

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生物活性

CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[2]

Cereblon

 

分子量

289.24

Formula

C13H11N3O5
CAS 号

1547162-46-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013;71(2):489-501.

    [2]. Makbul C, et al. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.

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