Pomalidomide-6-O-CH3 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Pomalidomide-6-O-CH3 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Pomalidomide-6-O-CH3 Chemical Structure

CAS No. : 1547163-08-5

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生物活性

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC^[1].

IC₅₀ & Target^[1]

Cereblon

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

303.27

Formula

C₁₄H₁₃N₃O₅

CAS 号

1547163-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

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