Ro 0437626

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ro 0437626 

Ro 0437626 是一种选择性嘌呤能 (P2X1) 受体拮抗剂 (IC50 = 3 μM)，但对 P2X2、P2X3 和 P2X2/3 受体的亲和力较低 (IC50 > 100 μM)。

Ro 0437626

Ro 0437626 Chemical Structure

CAS No. : 134362-79-1

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生物活性

Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1].

IC50 & Target

IC50: 3 μM (P2X1 receptor)
体外研究
(In Vitro)

Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rat (urethane-anaesthetized)[3]
Dosage: 1 and 10 μmol/kg
Administration: I.v.
Result: Caused a reduction in postinfusion isovolumetric contractions.

分子量

525.66

Formula

C27H35N5O4S
CAS 号

134362-79-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorg Med Chem Lett. 2005;15(13):3292-3295.

    [2]. Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8(7):1604-1613.

    [3]. King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142(3):519-530.

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