SW157765

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SW157765 

SW157765 是一种选择性非标准葡萄糖转运蛋白 GLUT8 (SLC2A8) 抑制剂。KRAS/KEAP1 双突变 NSCLC 细胞对 SW157765 选择性敏感，这是由于 KRAS 和 NRF2 双重调节代谢和异生基因调控程序的收敛结果。

SW157765

SW157765 Chemical Structure

CAS No. : 332063-87-3

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生物活性

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

体外研究
(In Vitro)

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

331.32

Formula

C19H13N3O3
CAS 号

332063-87-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269.

    [2]. McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.

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