VGSC blocker-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VGSC blocker-1

VGSC blocker 1 是 neonatal isoform of the VGSC subtype Nav1.5 (nNav1.5) 的有效小分子阻断剂。VGSC blocker 1 在人乳腺癌细胞系 MDA-MB-231 中，1 μM 处阻断 Ina 峰值电流 34.9%，在 1 μM 处抑制细胞侵袭 0.3%，且不影响细胞活力。

VGSC blocker-1 Chemical Structure

CAS No. : 2230472-55-4

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100 mg		询价
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500 mg		询价

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生物活性

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability^[1].

IC₅₀ & Target

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5)^[1].

体外研究
(In Vitro)

VGSC blocker 1 (compound 1) (1.0 to 10 μM) inhibits human breast cancer cell line MDA-MB-231^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	human breast cancer cell line MDA-MB-231
Concentration:	1.0 to 10μM
Incubation Time:	24 hours
Result:	VGSC blocker 1 blocks INa peak currents 34.9% at 1 uMa and inhibits cell invasion 0.3% at 1 uM. These values are much higher than the concentrations required (0.1 μM and 1 μM) to produce significant nNav1.5 current blockade and cell invasion inhibition.

分子量

386.52

Formula

C₂₄H₃₂F₂N₂

CAS 号

2230472-55-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Dutta S, et al. Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells. Bioorg Med Chem. 2018;26(9):2428-2436.

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