Gyrophoric acid is a good ultraviolet filter in lichen populations. Gyrophoric acid shows DPPH radical scavenging activity with an IC₅₀ value of 105.75 µg/ml^[1][2].

Gyrophoric acid (200 μM) leads to significant decrease of mitochondrial membrane potential in ovarian cancer cells A2780 after 24 h long exposure but not in HT-29 colon adenocarcinoma cells. Gyrophoric acid significantly inhibits cell growth and affects the expression of Bcl-2, Bax and Hsp70 proteins but only on higher concentration in A375 melanoma cancer cells. Gyrophoric acid treatment on HeLa cells clearly indicates ROS production and apoptosis as form of occurred cell death. Moreover, DNA damage and changing activity of stress/survival proteins as p38MAPK, Erk1/2 and Akt mediated by Gyrophoric acid treatment confirm pro-apoptotic potential^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

468.41

C₂₄H₂₀O₁₀

548-89-0

石耳酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kosanic M, et al. Biological activities and chemical composition of lichens from Serbia. EXCLI J. 2014;13:1226-1238. Published 2014 Nov 18.

  [2]. Goga M, et al. Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells. BMC Complement Altern Med. 2019;19(1):221. Published 2019 Aug 19.