Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Glychionide A (Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A 是一种黄酮苷，存在于 Glychirriza glabra 的根中。Glychionide A 促进 PANC-1 胰腺癌细胞的凋亡和自噬。Glychionide A 可用于癌症的研究。

Glychionide A(Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A Chemical Structure

CAS No. : 119152-50-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1].
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

446.36

Formula

C21H18O11
CAS 号

119152-50-0
中文名称

去甲汉黄芩素-7-O-葡萄糖醛酸苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.

    [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务