Norswertianin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Norswertianin 

Norswertianin 是一种氧杂蒽酮类化合物，是一种有效的抗神经胶质瘤化合物 (anti-glioma compound)。Norswertianin 通过氧化应激和 Akt/mTOR 依赖的自噬诱导 GBM 细胞分化。

Norswertianin

Norswertianin Chemical Structure

CAS No. : 22172-15-2

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生物活性

Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy[1].

体外研究
(In Vitro)

Norswertianin (12.5-50 µM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells[1].
Norswertianin (40 µM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest[1].
Norswertianin (40 µM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.20

Formula

C13H8O6
CAS 号

22172-15-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gordana Tovilovic-Kovacevic, et al. Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line. Phytomedicine

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