PP2A Cancerous-IN-1

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PP2A Cancerous-IN-1 

PP2A Cancerous-IN-1 是一种强效的 CIP2A (Cancerous inhibitor of PP2A)和 p-Akt 抑制剂。PP2A Cancerous-IN-1显示出很强的抗增殖活性。

PP2A Cancerous-IN-1

PP2A Cancerous-IN-1 Chemical Structure

CAS No. : 1403933-79-8

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生物活性

PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities[1].

IC50 & Target[1]

pAKT

 

体外研究
(In Vitro)

PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib[1].
PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis[1].
PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SK-Hep-1 cells
Concentration: 2.5 and 5 μM
Incubation Time: 24 hours
Result: Reduced cell viability with a dose dependent manner.

Western Blot Analysis[1]

Cell Line: SK-Hep-1 cells
Concentration: 2.5 and 5 μM
Incubation Time: 24 hours
Result: Reduced CIP2A expression.

Apoptosis Analysis[1]

Cell Line: SK-Hep-1 cells
Concentration: 2.5 and 5 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis.

分子量

488.54

Formula

C30H24N4O3
CAS 号

1403933-79-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen KF, et al. Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity. Bioorg Med Chem. 2012;20(20):6144-6153.

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