D-erythro-MAPP(Synonyms: D-e-MAPP)

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D-erythro-MAPP (Synonyms: D-e-MAPP)

D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂，其在体外的 IC50 值为 1-5 μM。

D-erythro-MAPP(Synonyms: D-e-MAPP)

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

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生物活性

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

体外研究
(In Vitro)

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.

分子量

361.56

Formula

C23H39NO2
CAS 号

143492-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919.

    [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.

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