D-erythro-MAPP(Synonyms: D-e-MAPP)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-MAPP (Synonyms: D-e-MAPP)

D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂，其在体外的 IC50 值为 1-5 μM。

D-erythro-MAPP(Synonyms: D-e-MAPP)

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

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生物活性

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

体外研究
(In Vitro)

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.

分子量

361.56

Formula

C23H39NO2
CAS 号

143492-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919.

    [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.

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