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WT IDH1 Inhibitor 2
WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。
WT IDH1 Inhibitor 2 Chemical Structure
CAS No. : 1816272-19-1
规格 | 价格 | 是否有货 | |
---|---|---|---|
5 mg | ¥9200 | 询问价格 & 货期 | |
10 mg | ¥14500 | 询问价格 & 货期 |
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生物活性 |
WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1]. |
IC50 & Target |
IC50: 120 nM (WT IDH1)[1] |
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体外研究 (In Vitro) |
WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
501.55 |
Formula |
C28H28FN5O3 |
CAS 号 |
1816272-19-1 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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