Isobutyl-deoxynyboquinone(Synonyms: IB-DNQ)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Isobutyl-deoxynyboquinone (Synonyms: IB-DNQ)

Isobutyl-deoxynyboquinone (IB-DNQ) 是 NAD(P)H:quinone oxidoreductase (NQO1) 的选择性底物。Isobutyl-deoxynyboquinone 可用于抗癌研究。

Isobutyl-deoxynyboquinone(Synonyms: IB-DNQ)

Isobutyl-deoxynyboquinone Chemical Structure

CAS No. : 1430798-22-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer[1].

体外研究
(In Vitro)

Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC cells) demonstrates greater cytotoxic potency against SCCF1 and SCCF2 cell lines, and less against the SCCF3 cell line. Isobutyl-deoxynyboquinone (0.1~3 μM; 60 minutes; SCCF1 cells) induces cytotoxicity in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Isobutyl-deoxynyboquinone (0.5~2 mg/kg; i.v.; 20 hours) achieves average peak plasma concentration levels. Isobutyl-deoxynyboquinone (1 mg/kg; p.o.; 4 hours) achieves peak plasma concentrations[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats
Dosage: 0.5~2 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Achieved average peak plasma concentration levels.
Animal Model: Cats
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Achieved peak plasma concentration.

分子量

326.35

Formula

C18H18N2O4

CAS 号

1430798-22-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lundberg AP, et al. Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species. Invest New Drugs. 2017;35(2):134-144.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务