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PR-104 sodium
PR-104 (sodium) 是一种选择性低氧活化 DNA 交联剂,可用于多种肿瘤异种移植模型的研究。PR-104 (sodium) 作为氮芥前药物有效地转化为亲脂性更强的二硝基苯甲酰胺芥菜醇 PR-104A。
![PR-104 sodium Chemical Structure PR-104 sodium](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-16406.gif)
PR-104 sodium Chemical Structure
CAS No. : 851627-80-0
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PR-104 sodium 的其他形式现货产品:
生物活性 |
PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-prodrug, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1]. |
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体外研究 (In Vitro) |
PR-104 (sodium) (80 μM; 1 hour; SiHa cells) shows greater suppression of radiation-induced DNA single-strand breaks under hypoxic than aerobic conditions. PR-104 (sodium) (100 μM; 1 hour; SiHa cells) results in phosphorylation of Ser139 of histone H2AX (gH2AX). PR-104 (sodium) (0.266 mmol/kg; 18 h; SiHa cells) shows activity against hypoxic cells after irradiation. PR-104 (sodium) varies in potency between cell lines, with the lowest IC50 (0.51 μmol/L) in H460 cells and highest (7.3 μmol/L) in PC3 prostate cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
PR-104 (sodium) (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (sodium) (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
601.25 |
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Formula |
C14H19BrN4NaO12PS |
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CAS 号 |
851627-80-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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