Pomalidomide-amino-PEG3-NH2 hydrochloride

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Pomalidomide-amino-PEG3-NH2 hydrochloride 

Pomalidomide-amino-PEG3-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

Pomalidomide-amino-PEG3-NH2 hydrochloride

Pomalidomide-amino-PEG3-NH2 hydrochloride Chemical Structure

CAS No. : 2380273-75-4

规格 是否有货
25 mg 询价
50 mg 询价

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生物活性

Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

498.91

Formula

C21H27ClN4O8
CAS 号

2380273-75-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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