(S,R,S)-AHPC-C2-NH2

发表于由

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(S,R,S)-AHPC-C2-NH2 

(S,R,S)-AHPC-C2-NH2 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个 linker，可用于合成 PROTAC。

(S,R,S)-AHPC-C2-NH2

(S,R,S)-AHPC-C2-NH2 Chemical Structure

CAS No. : 2241643-69-4

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(S,R,S)-AHPC-C2-NH2 的其他形式现货产品:

(S,R,S)-AHPC-C2-NH2 dihydrochloride

生物活性

(S,R,S)-AHPC-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

501.64

Formula

C25H35N5O4S
CAS 号

2241643-69-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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