6-Dehydrogingerdione

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6-Dehydrogingerdione 

6-Dehydrogingerdione 通过活性氧介导 DR5 的增加，使人肝母细胞瘤 Heg2 细胞对 TRAIL 诱导的凋亡敏感。

6-Dehydrogingerdione

6-Dehydrogingerdione Chemical Structure

CAS No. : 76060-35-0

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生物活性

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5[1].

体外研究
(In Vitro)

6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways[1].
6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation[1].
6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Hep G2 cells.
Concentration: 0, 50, 100 μM.
Incubation Time: 24 h.
Result: Induced Apoptosis in Hep G2 Cells.

分子量

290.35

Formula

C17H22O4
CAS 号

76060-35-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.

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