(Rac)-Shikonin(Synonyms: Shikalkin)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(Rac)-Shikonin (Synonyms: Shikalkin)

(Rac)-Shikonin (Shikonin) 具有抗肿瘤活性。(Rac)-Shikonin (Shikonin) 通过诱导坏死死亡来绕过癌症耐药性。

(Rac)-Shikonin(Synonyms: Shikalkin)

(Rac)-Shikonin Chemical Structure

CAS No. : 54952-43-1

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生物活性

(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer drug resistance by induction of a necroptotic death[1][2].

体外研究
(In Vitro)

Shikonin shows a similar potency toward drug-sensitive cancer cell lines (MCF-7 and HEK293) and their drug-resistant lines overexpressing P-glycoprotein, Bcl-2, or Bcl-xL, which account for most of the clinical cancer drug resistance[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

288.30

Formula

C16H16O5
CAS 号

54952-43-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. U Sankawa, Antitumor activity of shikonin and its derivatives. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2392-5.

    [2]. Weidong Han, et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther. 2007 May;6(5):1641-9.

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