Furanodiene(Synonyms: 莪术呋喃二烯)

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Furanodiene (Synonyms: 莪术呋喃二烯)

Furanodiene 是从姜黄中提取的天然萜类化合物。Furanodiene 通过抗血管生成和诱导 ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。Furanodiene 抑制外排转运蛋白 Pgp (P-glycoprotein) 功能并降低 Pgp 蛋白水平。

Furanodiene(Synonyms: 莪术呋喃二烯)

Furanodiene Chemical Structure

CAS No. : 19912-61-9

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生物活性

Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].

体外研究
(In Vitro)

Furanodiene (1.4, 4.1, 12.2 uM; 48 hours) is effective in treating human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into the zebrafish[1].
Furanodiene has no effect on Pgp related gene (MDR1) expression[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

216.32

Formula

C15H20O
CAS 号

19912-61-9
中文名称

莪术呋喃二烯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541.

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