Evocarpine(Synonyms: 吴茱萸新碱；吴茱萸卡品碱；吴茱萸喹酮碱)

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Evocarpine (Synonyms: 吴茱萸新碱；吴茱萸卡品碱；吴茱萸喹酮碱)

Evocarpine 是可从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，通过电压依赖性钙通道抑制 Ca2+ 内流。抗细菌活性。

Evocarpine(Synonyms: 吴茱萸新碱；吴茱萸卡品碱；吴茱萸喹酮碱)

Evocarpine Chemical Structure

CAS No. : 15266-38-3

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生物活性

Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2].

体外研究
(In Vitro)

Cumulative application of evocarpine (1-100 μM) inhibits the sustained contraction induced by 60 mM K+ in a concentration-dependent manner[1].
Evocarpine is found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose- and time-dependent manners[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

339.51

Formula

C23H33NO
CAS 号

15266-38-3
中文名称

吴茱萸新碱；吴茱萸卡品碱；吴茱萸喹酮碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J Yamahar, et al. The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action. Eur J Pharmacol. 1988 Oct 11;155(1-2):139-43.

    [2]. C Hochfellner, et al. Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 2015 Apr;118(4):864-72.

    [3]. N Y Kim, et al. Cyclic adenosine monophosphate inhibits quinolone alkaloid evocarpine-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 2000 Jul;87(1):1-5.

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