Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

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Aminohexylgeldanamycin hydrochloride (Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin (AHGDM) hydrochloride，Geldanamycin 的衍生物，是一种热休克蛋白 90 (HSP90) 抑制剂。Aminohexylgeldanamycin hydrochloride 具有抗血管生成和抗肿瘤活性。

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin hydrochloride Chemical Structure

CAS No. : 1146534-45-3

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Aminohexylgeldanamycin hydrochloride 的其他形式现货产品:

Aminohexylgeldanamycin

生物活性

Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

681.26

Formula

C34H53ClN4O8
CAS 号

1146534-45-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.

    [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

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