8-Bromo-ATP(Synonyms: 8-Bromoadenosine 5′-triphosphate; 8-Br-ATP)

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8-Bromo-ATP (Synonyms: 8-Bromoadenosine 5′-triphosphate; 8-Br-ATP)

8-Bromo-ATP (8-Bromoadenosine 5′-triphosphate)，一种 ATP 类似物，是一种嘌呤能 P2X receptor 受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性，IC50 为 23.1 μM。

8-Bromo-ATP(Synonyms: 8-Bromoadenosine 5

8-Bromo-ATP Chemical Structure

CAS No. : 23567-97-7

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生物活性

8-Bromo-ATP (8-Bromoadenosine 5′-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].

体外研究
(In Vitro)

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma[3].
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: MM 1.s cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time: 5 days
Result: Showed cytotoxic to multiple myeloma.

分子量

586.08

Formula

C10H15BrN5O13P3
CAS 号

23567-97-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).

    [2]. P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94.

    [3]. Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14.

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