TPP-1 TFA

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TPP-1 TFA 

TPP-1 TFA 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 TFA 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 TFA 通过再激活 T 细胞功能抑制肿瘤生长。

TPP-1 TFA

TPP-1 TFA Chemical Structure

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TPP-1 TFA 的其他形式现货产品:

TPP-1

生物活性

TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function[1].

体外研究
(In Vitro)

TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TPP-1 TFA (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1 TFA-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 TFA has no effect on the growth of the H460-luc tumors[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5- to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32 days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. 

分子量

2602.69

Formula

C109H151F3N34O34S2
Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6(2):178-188.

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