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SK33
SK33，肌醇类似物，是一种有效的组织选择性抗雄激素药物。SK33 降低雄激素受体 (AR) 的转录活性。
SK33 Chemical Structure
CAS No. : 1928724-23-5
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. |
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| 体外研究 (In Vitro) |
In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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| 体内研究 (In Vivo) |
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
500.31 |
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| Formula |
C20H13F9N2O3 |
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| CAS 号 |
1928724-23-5 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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