AD 01

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AD 01 

AD 01 是FKBPL (FK506-binding protein like)的24个氨基酸肽，具有有效的抗血管生成活性。AD 01 与CD44 受体结合，并以CD44依赖的方式抑制肿瘤细胞迁移。

AD 01

AD 01 Chemical Structure

CAS No. : 959961-23-0

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生物活性

AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner[1][2].

体内研究
(In Vivo)

AD 01 (≥0.003 mg/kg/day, ip) exhibits significant anti-tumor activity in DU145 tumors[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb-c severe compromised immuno-deficient (SCID) mice[1].
Dosage: 0.3 mg/kg/day.
Administration: I,P., for 14 days.
Result: Significantly lowered the tumor size.

分子量

2703.94

Formula

C115H187N33O42
CAS 号

959961-23-0
Sequence Shortening

QIRQQPRDPPTETLELEVSPDPAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Andrea Valentine, et al. FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res. 2011 Mar 1;17(5):1044-56.

    [2]. Anita Yakkundi, et al. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 2013;8(2):e55075.

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