HM03 trihydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HM03 trihydrochloride 

HM03 trihydrochloride是一种有效的选择性的热休克 70 kDa 蛋白 5, HSPA5 (也称为 Bip，Grp78) 抑制剂，具有抗肿瘤活性。

HM03 trihydrochloride

HM03 trihydrochloride Chemical Structure

CAS No. : 1082532-95-3

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HM03 trihydrochloride 的其他形式现货产品:

HM03

生物活性

HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].

体外研究
(In Vitro)

HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1].
HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1].
HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

572.35

Formula

C26H30Cl4N4O2
CAS 号

1082532-95-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044-3050.

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