上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Melflufen (Synonyms: Melphalan flufenamide)
Melflufen (Melphalan flufenamide),Melphalan 的一种二肽前体药物,是一种烷基化剂。Melflufen 对多发性骨髓瘤细胞具有抗肿瘤活性,并抑制血管生成。Melflufen 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。
Melflufen Chemical Structure
CAS No. : 380449-51-4
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Melflufen 的其他形式现货产品:
生物活性 |
Melflufen (Melphalan flufenamide), a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3]. |
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体外研究 (In Vitro) |
Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay
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体内研究 (In Vivo) |
Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
498.42 |
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Formula |
C24H30Cl2FN3O3 |
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CAS 号 |
380449-51-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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