AMG-Tie2-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AMG-Tie2-1 

AMG-Tie2-1 是一种内膜内皮细胞激酶 2 (Tie2) 抑制剂，IC50 为 1 nM。AMG-Tie2-1 是一种 VEGFR2 抑制剂，IC50 为 3 nM。

AMG-Tie2-1

AMG-Tie2-1 Chemical Structure

CAS No. : 870223-96-4

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生物活性

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1].

体外研究
(In Vitro)

AMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM).

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.45

Formula

C25H20F3N5O2
CAS 号

870223-96-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brian L Hodous, et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26.

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