Squarunkin A hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Squarunkin A hydrochloride 

Squarunkin A hydrochloride 是一种有效的选择性 UNC119-货物相互作用抑制剂 (IC50 为 10 nM，用于抑制 UNC119A-肉豆蔻酰化的 Src N 末端肽相互作用)。Squarunkin A hydrochloride 会干扰细胞中 Src 激酶的活化。

Squarunkin A hydrochloride

Squarunkin A hydrochloride Chemical Structure

CAS No. : 2253744-55-5

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生物活性

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].

IC50 & Target

IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]
体外研究
(In Vitro)

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation[1].
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

560.01

Formula

C25H33ClF3N5O4
CAS 号

2253744-55-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186.

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