Squarunkin A hydrochloride

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Squarunkin A hydrochloride 

Squarunkin A hydrochloride 是一种有效的选择性 UNC119-货物相互作用抑制剂 (IC50 为 10 nM，用于抑制 UNC119A-肉豆蔻酰化的 Src N 末端肽相互作用)。Squarunkin A hydrochloride 会干扰细胞中 Src 激酶的活化。

Squarunkin A hydrochloride

Squarunkin A hydrochloride Chemical Structure

CAS No. : 2253744-55-5

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生物活性

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].

IC50 & Target

IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]
体外研究
(In Vitro)

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation[1].
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

560.01

Formula

C25H33ClF3N5O4
CAS 号

2253744-55-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186.

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