Datelliptium chloride hydrochloride

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Datelliptium chloride hydrochloride 

Datelliptium chloride hydrochloride 是一种由 Ellipticine (HY-15753) 衍生的 DNA 嵌合剂。Datelliptium chloride hydrochloride 在体内对多种小鼠实体瘤有效。

Datelliptium chloride hydrochloride

Datelliptium chloride hydrochloride Chemical Structure

CAS No. : 157000-76-5

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Datelliptium chloride hydrochloride 的其他形式现货产品:

Datelliptium chloride

生物活性

Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors[1][2].

体外研究
(In Vitro)

Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo[2].
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease[2].
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice, colon adenocarcinoma early staged disease model[2]
Dosage: 170 mg/kg
Administration: Intravenous injection, for 12 days
Result: Showed potent activity against colon adenocarcinoma.

分子量

434.40

Formula

C23H29Cl2N3O
CAS 号

157000-76-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302.

    [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.

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