Umbralisib R-enantiomer(Synonyms: TGR-1202 R-enantiomer; RP5264 R-enantiomer)

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Umbralisib R-enantiomer (Synonyms: TGR-1202 R-enantiomer; RP5264 R-enantiomer) 纯度: 99.52%

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) 是 PI3Kδ 抑制剂,是 TGR-1202 活性较低的对映体。

Umbralisib R-enantiomer(Synonyms: TGR-1202 R-enantiomer;  RP5264 R-enantiomer)

Umbralisib R-enantiomer Chemical Structure

CAS No. : 1532533-69-9

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Umbralisib R-enantiomer 相关产品

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生物活性

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.

IC50 & Target[1]

PI3Kδ

 

体外研究
(In Vitro)

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor’s IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

571.55

Formula

C31H24F3N5O3

CAS 号

1532533-69-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1.

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