NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage^[1].

NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression^[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

512.35

C₂₄H₂₂BrN₃O₅

101982-51-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Glaros TG, et al. The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212.