Kurarinol(Synonyms: 苦参醇)

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Kurarinol (Synonyms: 苦参醇)

Kurarinol 是一种黄烷酮,在 Sophora flavescens 根中被发现。Kurarinol 是一种竞争性的酪氨酸酶 (tyrosinase) 抑制剂,对蘑菇型酪氨酸酶作用的 IC50 为 0.1 μM 。

Kurarinol(Synonyms: 苦参醇)

Kurarinol Chemical Structure

CAS No. : 855746-98-4

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生物活性

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].

IC50 & Target

IC50: 0.1 μM (mushroom tyrosinase)[1]

体外研究
(In Vitro)

Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1].
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1].
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3]
Dosage: 20 mg/kg
Administration: Oral administration, daily, for 3 days
Result: Decreased serum TC, TG, and LDL-C levels.

分子量

456.53

Formula

C26H32O7

CAS 号

855746-98-4

中文名称

苦参醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.

    [2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.

    [3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.

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