Silybin(Synonyms: 水飞蓟宾)

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Silybin (Synonyms: 水飞蓟宾)

Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis)，并具有保肝，抗氧化，抗炎，抗癌活性。

Silybin(Synonyms: 水飞蓟宾)

Silybin Chemical Structure

CAS No. : 802918-57-6

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生物活性

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

体外研究
(In Vitro)

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner[1].
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%[1].
Silybin (68 μM; for 72 hours) induces AKT activity inhibition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell growth
Concentration: 0-200 mM
Incubation Time: For 72 hours
Result: Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.

Western Blot Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced AKT activity inhibition.

体内研究
(In Vivo)

Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage: 50, 100 mg/kg
Administration: Given intragastrically; daily; for the last 4 weeks
Result: Significantly lowered both serum and hepatic lipid accumulation.

Clinical Trial

分子量

482.44

Formula

C25H22O10
CAS 号

802918-57-6
中文名称

水飞蓟宾
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190.

    [2]. Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

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