Purpurin 18 methyl ester

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Purpurin 18 methyl ester 

Purpurin 18 methyl ester，叶绿素 a 的衍生物，是一种可用于光动力疗法 (PDT) 的光敏剂。Purpurin 18 methyl ester 具有光动力学活性，可诱导癌细胞死亡。

Purpurin 18 methyl ester

Purpurin 18 methyl ester Chemical Structure

CAS No. : 51744-55-9

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生物活性

Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death[1].

体外研究
(In Vitro)

Purpurin 18 methyl ester (1-5 μg/mL; 24 h) has no cytotoxicity in dark in HepG-2 cells[1].
Purpurin 18 methyl ester (1-5 μg/mL; 24 h) decreases the viability of HepG-2 cells in a concentration-dependent manner with irradiation for 10 min[1].
Purpurin 18 methyl ester (0-24 h) is released from GO- Purpurin 18 methyl ester (Pu18) composite, with rates of 47%, 22% and 30% in weak acidic condition (pH 5.6), neutral environment (pH 7.4) and weak alkali condition (pH 8.9) for 24 h, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

578.66

Formula

C34H34N4O5
CAS 号

51744-55-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et, al. pH-Sensitive graphene oxide conjugate Purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy. New Journal of Chemistry. 2018 Jun 26; 42(16):13272-13284.

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