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7-Hydroxymethotrexate (Synonyms: 7-羟基甲氨蝶呤)
7-Hydroxymethotrexate 是 Methotrexate (MTX; HY-14519) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂，可以抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。
7-Hydroxymethotrexate Chemical Structure
CAS No. : 5939-37-7
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| 生物活性 |
7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2]. |
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| 体外研究 (In Vitro) |
7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) [1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
470.44 |
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| Formula |
C20H22N8O6 |
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| CAS 号 |
5939-37-7 |
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| 中文名称 |
7-羟基甲氨蝶呤 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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