UNC2399

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

UNC2399 

UNC2399，一种生物素化的 UNC1999，是选择性的 EZH2 降解剂，对 EZH2 具有很高的体外效力，IC50 值为 17 nM。

UNC2399

UNC2399 Chemical Structure

CAS No. : 2412791-72-9

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生物活性

UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].

IC50 & Target[1]

EZH2

17 nM (IC50)

体外研究
(In Vitro)

UNC2399 (1-1000 nM) displays high in vitro potency (IC50=17±2 nM) in the EZH2 radioactive biochemical assay[1].
UNC2399 (100 μM) enriches EZH2 from HEK293T cell lysates[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

927.17

Formula

C48H66N10O7S
CAS 号

2412791-72-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8(6): 1324-34.

    [2]. Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.

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