Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication^[1].

The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

753.84

C₄₄H₄₃N₅O₇

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• [1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.