StRIP16

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

StRIP16 

StRIP16 是可生物利用的 StRIP3 类似物，是一种可与 Rab8a GTPase 结合的双钉肽，Kd 值为 12.7 μM。

StRIP16

StRIP16 Chemical Structure

规格 是否有货
500 μg 询价

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生物活性

StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM[1].

IC50 & Target

Kd: 12.7 μM (Rab8a GTPase)[1]
体外研究
(In Vitro)

StRIP16 shows selectivity for Rab8 over other Rab-GTPases and does not engage H-Ras or N-Ras (rel. Kd=~10, ~25, ~35, 1.0, ~10, >100, >50, and >100 for Rab1b, Rab5a, Rab6a, Rab8a, Rab9a, Rab11a, H- and N-Ras respectively)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2300.65

Formula

C98H138N20O22
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cromm PM, et, al. Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol. 2016 Aug 19;11(8):2375-82.

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