Aliskiren D6 hemifumarate(Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aliskiren D6 hemifumarate (Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

Aliskiren D6 hemifumarate (CGP 60536 D6 hemifumarate) 是 Aliskiren hemifumarate 的氘代物。Aliskiren hemifumarate 是一种直接的口服活性的肾素 (renin) 抑制剂，IC50 为 1.5 nM。

Aliskiren D6 hemifumarate(Synonyms: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate)

Aliskiren D6 hemifumarate Chemical Structure

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生物活性

Aliskiren D6 hemifumarate (CGP 60536 D6 hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].

IC50 & Target

IC50: 1.5 nM (renin)[1]
分子量

615.83

Formula

C34H51D6N3O10
中文名称

阿利克仑半富马酸盐 D6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754-758.

    [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.

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