F1324 acetate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

F1324 acetate 

F1324 acetate 是一种有效、高亲和力的 BCL6 多肽抑制剂，IC50 值为 1 nM。F1324 acetate 结合 BCL6 动力学 t1/2 为 441 s, 对 BCL6 PPI 具有很强的抑制作用。

F1324 acetate

F1324 acetate Chemical Structure

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生物活性

F1324 acetate is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 acetate exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].

IC50 & Target

IC50: 1 nM (BCL6)[1]
体外研究
(In Vitro)

F1324 acetate binds to BCL6(5-129) with KD and IC50 values of 0.57 nM and 1 nM according to the results of an SPR analysis and cell-free ELISA assay, respectively[1].
F1324 acetate binds BCL6 not only in cell-free but also cellbased conditions[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1825.09

Formula

C2H4O2
Sequence Shortening

Ac-LWYTDIRMSWRVP-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482(2):310-316.

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